It was a little over ten years ago, 1967–8, that H. D. Lewis delivered the first series of Gifford lectures, The Elusive Mind, in the University of Edinburgh. It was my privilege that year to be an auditor in the Seminar at King's College that Professor Lewis was conducting with his students in the area of this topic. I had already read the works in which, in the midst of neo-orthodox and existentialist religious movements, he had devoted himself (...) to critical valuation of those doctrines - witness his Morals and the New Theology, and Morals and Revelation. This earlier work prepared for a comprehensive interpretation of religious experience in his book in 1960: Our Experience of God. (shrink)

Background: nursing students are required to think reflectively in both real and simulated clinical practice. Although the Reflective Thinking instrument is reliable in its measurement of reflective thinking, its validity is unknown. Method: confirmatory factor analysis was undertaken in an iterative manner within a non-equivalent control-group study to measure nursing students’ reflective thinking and satisfaction with high-fidelity simulation. The validity and reliability of the Reflective Thinking instrument was tested. Results: the resulting instrument consisted of 15 items across four factors. The (...) final model was plausible as it demonstrated ‘goodness of fit’; however, it had neither convergent or discriminatory validity, nor reliability. Internal consistency was fair to reasonable for the four subscales. Conclusion: the testing of the Reflective Thinking instrument using confirmatory factor analysis is a vital initial step in the modification of this instrument. Further development using exploratory factor analysis will enhance the instrument’s relevance within high-fidelity simulation. (shrink)

Mood has varied effects on cognitive performance including the accuracy of face recognition . Three experiments are presented here that explored face recognition abilities in mood-induced participants. Experiment 1 demonstrated that happy-induced participants are less accurate and have a more conservative response bias than sad-induced participants in a face recognition task. Using a remember/know/guess procedure, Experiment 2 showed that sad-induced participants had more conscious recollections of faces than happy-induced participants. Additionally, sad-induced participants could recognise all faces accurately, whereas, happy- and (...) neutral-induced participants recognised happy faces more accurately than sad faces. In Experiment 3, these effects were not observed when participants intentionally learnt the faces, rather than incidentally learnt the faces. It is suggested that happy-induced participants do not process faces as elaborately as sad-induced participants. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

David Lewis has offered a reply to the standard argument for the claim that the truth of determinism is incompatible with anyone’s being able to do otherwise than she in fact does. Helen Beebee has argued that Lewis’s compatibilist strategy is untenable. In this paper I show that one recent attempt to defend Lewis’s view against this argument fails and then go on to offer my own defense of Lewis’s view.

According to a recent paper by Tim Maudlin, Bell’s theorem has nothing to tell us about realism or the descriptive completeness of quantum mechanics. What it shows is that quantum mechanics is non-local, no more and no less. What I intend to do in this paper is to challenge Maudlin’s assertion about the import of Bell’s proof. There is much that I agree with in the paper; in particular, it does us the valuable service of demonstrating that Einstein’s objections to (...) quantum mechanics have nothing to do with its indeterminism. But I do think that Maudlin’s conclusion is overly cut-and-dried. Quantum mechanics is far from a unified edifice, and what Bell’s theorem shows depends on what version of quantum mechanics you look at. In particular, I’ll try to make the case that there’s an interesting, if ultimately uncompelling anti-realist construal of the import of Bell’s theorem. And I also want to suggest that locality isn’t quite as decisively defeated as Maudlin claims. (shrink)

H. D. Lewis gave the Gifford Lectures at Edinburgh in 1966–1968. In The Elusive Mind and in The Elusive Self he expanded on the substance of the Lectures devoted to the defense of mind-body dualism and the self-identity of the person, respectively. The present book “rounds off” the first part of the final volume, The Elusive Self and God. Once more we are indebted to Lewis’s surgical finesse as he defends his libertarian view of free will against both (...) more familiar objections and recent ones—as in Nowell-Smith, Elizabeth Anscombe, and Donald Davidson. This review is confined to key theses in Lewis’s concept of the self as moral agent. (shrink)

BackgroundThe areas of Research Ethics (RE) and Research Integrity (RI) are rapidly evolving. Cases of research misconduct, other transgressions related to RE and RI, and forms of ethically questionable behaviors have been frequently published. The objective of this scoping review was to collect RE and RI cases, analyze their main characteristics, and discuss how these cases are represented in the scientific literature.MethodsThe search included cases involving a violation of, or misbehavior, poor judgment, or detrimental research practice in relation to a (...) normative framework. A search was conducted in PubMed, Web of Science, SCOPUS, JSTOR, Ovid, and Science Direct in March 2018, without language or date restriction. Data relating to the articles and the cases were extracted from case descriptions.ResultsA total of 14,719 records were identified, and 388 items were included in the qualitative synthesis. The papers contained 500 case descriptions. After applying the eligibility criteria, 238 cases were included in the analysis. In the case analysis, fabrication and falsification were the most frequently tagged violations (44.9%). The non-adherence to pertinent laws and regulations, such as lack of informed consent and REC approval, was the second most frequently tagged violation (15.7%), followed by patient safety issues (11.1%) and plagiarism (6.9%). 80.8% of cases were from the Medical and Health Sciences, 11.5% from the Natural Sciences, 4.3% from Social Sciences, 2.1% from Engineering and Technology, and 1.3% from Humanities. Paper retraction was the most prevalent sanction (45.4%), followed by exclusion from funding applications (35.5%).ConclusionsCase descriptions found in academic journals are dominated by discussions regarding prominent cases and are mainly published in the news section of journals. Our results show that there is an overrepresentation of biomedical research cases over other scientific fields compared to its proportion in scientific publications. The cases mostly involve fabrication, falsification, and patient safety issues. This finding could have a significant impact on the academic representation of misbehaviors. The predominance of fabrication and falsification cases might diverge the attention of the academic community from relevant but less visible violations, and from recently emerging forms of misbehaviors. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

Interpretations of Quantum Mechanics Quantum mechanics is a physical theory developed in the 1920s to account for the behavior of matter on the atomic scale. It has subsequently been developed into arguably the most empirically successful theory in the history of physics. However, it is hard to understand quantum mechanics as a description of the … Continue reading Quantum Mechanics, Interpretations of →.

Interpretations of Quantum Mechanics Quantum mechanics is a physical theory developed in the 1920s to account for the behavior of matter on the atomic scale. It has subsequently been developed into arguably the most empirically successful theory in the history of physics. However, it is hard to understand quantum mechanics as a description of the … Continue reading Quantum Mechanics, Interpretations of →.

This article examines methodological and ethical issues of ethnographic research through the lens of Emmanuel Levinas's philosophy. Levinas is relevant to a critical analysis of ethnographic methods because his philosophy turns on the problematic relationship between self and other, among other important problems that define and guide contemporary anthropological research, including questions of responsibility, justice, and solidarity. This article utilizes Levinas's philosophy to outline a phenomenology of the “doing” of fieldwork, emphasizing the contingency of face-to-face encounters over controlled research design. (...) This account provides a basis for going beyond the polarized opposition between objective and subjective ethnographic approaches. Levinas allows for an ethically informed ethnography premised upon an acknowledgement of risk and uncertainity over researcher control or reflexivity. Providing a handful of concrete examples, the article argues that critical self-reflection about the fundamental face-to-face dimension of fieldwork is central to ethnography's ethical possibilities. (shrink)

Metaphysicians should pay attention to quantum mechanics. Why? Not because it provides definitive answers to many metaphysical questions-the theory itself is remarkably silent on the nature of the physical world, and the various interpretations of the theory on offer present conflicting ontological pictures. Rather, quantum mechanics is essential to the metaphysician because it reshapes standard metaphysical debates and opens up unforeseen new metaphysical possibilities. Even if quantum mechanics provides few clear answers, there are good reasons to think that any adequate (...) understanding of the quantum world will result in a radical reshaping of our classical world-view in some way or other. Whatever the world is like at the atomic scale, it is almost certainly not the swarm of particles pushed around by forces that is often presupposed. This book guides readers through the theory of quantum mechanics and its implications for metaphysics in a clear and accessible way. The theory and its various interpretations are presented with a minimum of technicality. The consequences of these interpretations for metaphysical debates concerning realism, indeterminacy, causation, determinism, holism, and individuality are explored in detail, stressing the novel form that the debates take given the empirical facts in the quantum domain. While quantum mechanics may not deliver unconditional pronouncements on these issues, the range of possibilities consistent with our knowledge of the empirical world is relatively small-and each possibility is metaphysically revisionary in some way. This book will appeal to researchers, students, and anybody else interested in how science informs our world-view. (shrink)

Putnam and Laudan separately argue that the falsity of past scientific theories gives us reason to doubt the truth of current theories. Their arguments have been highly influential, and have generated a significant literature over the past couple of decades. Most of this literature attempts to defend scientific realism by attacking the historical evidence on which the premises of the relevant argument are based. However, I argue that both Putnam's and Laudan's arguments are fallacious, and hence attacking their premises is (...) unnecessary. The paper concludes with a discussion of the further historical evidence that would be required if the pessimistic induction is to present a serious threat to scientific realism. (shrink)

Putnam and Laudan separately argue that the falsity of past scientific theories gives us reason to doubt the truth of current theories. Their arguments have been highly influential, and have generated a significant literature over the past couple of decades. Most of this literature attempts to defend scientific realism by attacking the historical evidence on which the premises of the relevant argument are based. However, I argue that both Putnam's and Laudan's arguments are fallacious, and hence attacking their premises is (...) unnecessary. The paper concludes with a discussion of the further historical evidence that would be required if the pessimistic induction is to present a serious threat to scientific realism. (shrink)

This paper investigates the tenability of wavefunction realism, according to which the quantum mechanical wavefunction is not just a convenient predictive tool, but is a real entity figuring in physical explanations of our measurement results. An apparent difficulty with this position is that the wavefunction exists in a many-dimensional configuration space, whereas the world appears to us to be three-dimensional. I consider the arguments that have been given for and against the tenability of wavefunction realism, and note that both the (...) proponents and the opponents assume that quantum mechanical configuration space is many-dimensional in exactly the same sense in which classical space is three-dimensional. I argue that this assumption is mistaken, and that configuration space can be taken as three-dimensional in a relevant sense. I conclude that wavefunction realism is far less problematic than it has been taken to be. Introduction Non-separability The instantaneous solution The dynamical solution Invariance What is configuration space, anyway? Conclusion. (shrink)

The Sleeping Beauty paradox in epistemology and the many-worlds interpretation of quantum mechanics both raise problems concerning subjective probability assignments. Furthermore, there are striking parallels between the two cases; in both cases personal experience has a branching structure, and in both cases the agent loses herself among the branches. However, the treatment of probability is very different in the two cases, for no good reason that I can see. Suppose, then, that we adopt the same treatment of probability in each (...) case. Then the dominant ‘thirder’ solution to the Sleeping Beauty paradox becomes incompatible with the tenability of the many-worlds interpretation. (shrink)

In quantum mechanics it is usually assumed that mutually exclusives states of affairs must be represented by orthogonal vectors. Recent attempts to solve the measurement problem, most notably the GRW theory, require the relaxation of this assumption. It is shown that a consequence of relaxing this assumption is that arithmatic does not apply to ordinary macroscopic objects. It is argued that such a radical move is unwarranted given the current state of understanding of the foundations of quantum mechanics.

Everettian accounts of quantum mechanics entail that people branch; every possible result of a measurement actually occurs, and I have one successor for each result. Is there room for probability in such an account? The prima facie answer is no; there are no ontic chances here, and no ignorance about what will happen. But since any adequate quantum mechanical theory must make probabilistic predictions, much recent philosophical labor has gone into trying to construct an account of probability for branching selves. (...) One popular strategy involves arguing that branching selves introduce a new kind of subjective uncertainty. I argue here that the variants of this strategy in the literature all fail, either because the uncertainty is spurious, or because it is in the wrong place to yield probabilistic predictions. I conclude that uncertainty cannot be the ground for probability in Everettian quantum mechanics. (shrink)

This article provides an overview of the philosophical literature on the GRW theory of quantum mechanics, and argues for a particular position regarding that literature. Much of the literature is ontological; it attempts to defend a conception of what the world is like according to the GRW theory against perceived competitors. I argue that there is no real debate here, since these supposedly conflicting positions are better regarded as alternative and compatible ways of describing the world of the GRW theory.

Recently, Richard Healey and Simon Friederich have each advocated a pragmatist interpretation of quantum mechanics as a way to dissolve its foundational problems. The idea is that if we concentrate on the way quantum claims are used, the foundational problems of quantum mechanics cannot be formulated, and so do not require solution. Their central contention is that the content of quantum claims differs from the content of non-quantum claims, in that the former is prescriptive whereas the latter is descriptive. Healey (...) also argues that claims about non-decoherent systems are largely devoid of content. I consider various objections to these claims, noting in particular the ways in which the application of pragmatism to quantum mechanics differs from previous examples of pragmatist therapy. I conclude that a pragmatist dissolution of the foundational difficulties of quantum mechanics is promising, but requires fairly radical changes to our understanding of the content of propositions and the extent of physical explanation. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Everettian accounts of quantum mechanics entail that people branch; every possible result of a measurement actually occurs, and I have one successor for each result. Is there room for probability in such an account? The prima facie answer is no; there are no ontic chances here, and no ignorance about what will happen. But since any adequate quantum mechanical theory must make probabilistic predictions, much recent philosophical labor has gone into trying to construct an account of probability for branching selves. (...) One popular strategy involves arguing that branching selves introduce a new kind of subjective uncertainty. I argue here that the variants of this strategy in the literature all fail, either because the uncertainty is spurious, or because it is in the wrong place to yield probabilistic predictions. I conclude that uncertainty cannot be the ground for probability in Everettian quantum mechanics. (shrink)

The main difficulty facing no-collapse theories of quantum mechanics in the Everettian tradition concerns the role of probability within a theory in which every possible outcome of a measurement actually occurs. The problem is two-fold: First, what do probability claims mean within such a theory? Second, what ensures that the probabilities attached to measurement outcomes match those of standard quantum mechanics? Deutsch has recently proposed a decision-theoretic solution to the second problem, according to which agents are rationally required to weight (...) the outcomes of measurements according to the standard quantum-mechanical probability measure. I show that this argument admits counterexamples, and hence fails to establish the standard probability weighting as a rational requirement. (shrink)

Drawing together researchers from diverse theoretical positions, the aim of this book is to work towards a coherent and unified account of how we develop an understanding of one's and others' mental states.

Deception has long been an important topic in philosophy. However, the traditional analysis of the concept, which requires that a deceiver intentionally cause her victim to have a false belief, rules out the possibility of much deception in the animal kingdom. Cognitively unsophisticated species, such as fireflies and butterflies, have simply evolved to mislead potential predators and/or prey. To capture such cases of “functional deception,” several researchers Machiavellian intelligence II, Cambridge University Press, Cambridge, pp 112–143, 1997; Searcy and Nowicki, The (...) evolution of animal communication, Princeton University Press, Princeton, 2005; Skyrms, Signals, Oxford University Press, Oxford 2010) have endorsed the broader view that deception only requires that a deceiver benefit from sending a misleading signal. Moreover, in order to facilitate game-theoretic study of deception in the context of Lewisian sender-receiver games, Brian Skyrms has proposed an influential formal analysis of this view. Such formal analyses have the potential to enhance our philosophical understanding of deception in humans as well as animals. However, as we argue in this paper, Skyrms’s analysis, as well as two recently proposed alternative analyses, are seriously flawed and can lead us to draw unwarranted conclusions about deception. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

It has long been recognized that a local hidden variable theory of quantum mechanics can in principle be constructed, provided one is willing to countenance pre-measurement correlations between the properties of measured systems and measuring devices. However, this ‘conspiratorial’ approach is typically dismissed out of hand. In this article I examine the justification for dismissing conspiracy theories of quantum mechanics. I consider the existing arguments against such theories, and find them to be less than conclusive. I suggest a more powerful (...) argument against the leading strategy for constructing a conspiracy theory. Finally, I outline two alternative strategies for constructing conspiracy theories, both of which are immune to these arguments, but require one to either modify or reject the common cause principle. Introduction The incompleteness of quantum mechanics Hidden variables Hidden mechanism conspiracy theories Existing arguments against hidden mechanisms A new argument against hidden mechanisms Backwards-causal conspiracy theories Acausal conspiracy theories Conclusion. (shrink)

All parties to the Sleeping Beauty debate agree that it shows that some cherished principle of rationality has to go. Thirders think that it is Conditionalization and Reflection that must be given up or modified; halfers think that it is the Principal Principle. I offer an analysis of the Sleeping Beauty puzzle that allows us to retain all three principles. In brief, I argue that Sleeping Beauty’s credence in the uncentered proposition that the coin came up heads should be 1/2, (...) but her credence in the centered proposition that the coin came up heads and it is Monday should be 1/3. I trace the source of the earlier mistakes to an unquestioned assumption in the debate, namely that an uncentered proposition is just a special kind of centered proposition. I argue that the falsity of this assumption is the real lesson of the Sleeping Beauty case. (shrink)

I examine recent arguments based on functionalism that claim to show that Bohm's theory fails to solve the measurement problem, or if it does so, it is only because it reduces to a form of the many-worlds theory. While these arguments reveal some interesting features of Bohm's theory, I contend that they do not undermine the distinctive Bohmian solution to the measurement problem. ‡I would like to thank Harvey Brown, Martin Thomson-Jones, and David Wallace for helpful discussions. †To contact the (...) author, please write to: Department of Philosophy, University of Miami, P.O. Box 248054, Coral Gables, FL 33124–4670; e-mail: [email protected]. (shrink)

I argue that the Doomsday argument fails because it fails to take into account the lesson of the Sleeping Beauty puzzle.

There is a recurring line of argument in the literature to the effect that Bohm's theory fails to solve the measurement problem. I show that this argument fails in all its variants. Hence Bohm's theory, whatever its drawbacks, at least succeeds in solving the measurement problem. I briefly discuss a similar argument that has been raised against the GRW theory.

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Measures of epistemic utility are used by formal epistemologists to make determinations of epistemic betterness among cognitive states. The Brier rule is the most popular choice among formal epistemologists for such a measure. In this paper, however, we show that the Brier rule is sometimes seriously wrong about whether one cognitive state is epistemically better than another. In particular, there are cases where an agent gets evidence that definitively eliminates a false hypothesis, but where the Brier rule says that things (...) have become epistemically worse. Along the way to this ‘elimination experiment’ counter-example to the Brier rule as a measure of epistemic utility, we identify several useful monotonicity principles for epistemic betterness. We also reply to several potential objections to this counter-example. (shrink)